薛松果
所在医院：
上海东方医院
三级甲等
所在科室：
生殖医学科
医生简介:
展开
学术职务：
上海市医学会生殖医学分会青年委员
擅长：
临床胚胎学 （1）对受精失败、低受精率有丰富处理经验； （2）对反复胚胎差有丰富处理经验； （3）对卵子成熟障碍有丰富处理经验； （4）2007年开始推广胚胎玻璃化冷冻，2008-2010连续三年举办胚胎玻璃化冷冻培训班； （5）原创Cryopiece单精子冷冻（国内较前例单精子冷冻试管婴儿，2016），2017-2020连续四年举办单精子冷冻培训班。
发表文章：
第一或通讯作者（含共同第一或共同通讯） 1.Xu Y, Wang R, Pang Z, Wei Z, Sun L, Li S, Wang G, Liu Y, Zhou Y, Ye H, Jin L, Xue S. Novel Homozygous PADI6 Variants in Infertile Females with Early Embryonic Arrest[J]. Front Cell Dev Biol. 2022 Apr 1;10:819667. doi: 10.3389/fcell.2022.819667. eCollection 2022. 2.Yu K, Wang RX, Li MH, Sun TC, Zhou YW, Li YY, Sun LH, Zhang BL, Lian ZX, Xue SG, Liu YX, Deng SL. Melatonin Reduces Androgen Production and Upregulates Heme Oxygenase-1 Expression in Granulosa Cells from PCOS Patients with Hypoestrogenia and Hyperandrogenia[J]. Oxid Med Cell Longev. 2019 Oct 20;2019:8218650. doi: 10.1155/2019/8218650. eCollection 2019.PMID: 31772710 3.Sun L, Tian H, Xue S, Ye H, Xue X, Wang R, Liu Y, Zhang C, Chen Q, Gao S. Tie1 contributes to the development of ovarian hyperstimulation syndrome under the regulation of EGR1 in granulosa cells[J]. Exp Mol Med. 2022 Jan;54(1):81-90. doi: 10.1038/s12276-021-00722-8. Epub 2022 Jan 25.PMID: 35079118 4.Zhao, L#, Xue, S#, Yao, Z#. et al. Biallelic mutations in CDC20 cause female infertility characterized by abnormalities in oocyte maturation and early embryonic development. Protein Cell (2020). https://doi.org/10.1007/s13238-020-00756-0 5.中国男性生育力保存专家共识编写组（专家）. 中国男性生育力保存专家共识[J]. 中华生殖与避孕, 2021, 41(3):191-198 DOI: 10.3760/cma.j.cn101441-20200831-00469. 6.王荣祥,喻乔,彭秋平,曹少锋,张彩霞,刘宇,周怡雯,薛松果.自制冷冻片微型载体（Strawtop）微量精液冻存效果的实验研究[J].中华生殖与避孕杂志,2020,40(12):1006-1012.DOI:10.3760/cma.j.cn101441-20191014-00458. 7.Yao Xu, Ying Qian, Yu Liu, Qiaofeng Wang, Rongxiang Wang, Yiwen Zhou, Caixia Zhang, Zhi Pang, Hongjuan Ye, Songguo Xue*, Lihua Sun*. A novel homozygous variant in NLRP5 is associate with human early embryonic arrest in a consanguineous Chinese family. Clin Genet. 2020 Mar 29. doi: 10.1111/cge.13744. Online ahead of print. 8.Yu, Kun, Wang, Rong-Xiang, Li, Meng-Hui, Sun, Tie-Cheng, Zhou, Yi-Wen, Li, Yuan-Yuan, Sun, Li-Hua, Zhang, Bao-Lu, Lian, Zheng-Xing*, Xue, Song-Guo*, Liu, Yi-Xun, Deng, Shou-Long*. Melatonin Reduces Androgen Production and Upregulates Heme Oxygenase-1 Expression in Granulosa Cells from PCOS Patients , with Hypoestrogenia and Hyperandrogenia. Oxidative Medicine and Cellular Longevity, 2019 Oct 20;2019:8218650. doi: 10.1155/2019/8218650. eCollection 2019. 9.Yao Wang, Mei-lin Zhang, Lei-wen Zhao, Yan-ping Kuang, Song-guo Xue*. Enhancement of the efficiency of oocyte vitrification through regulation of histone deacetylase 6 expression. J Assist Reprod Genet. 2018 Jul; 35(7):1179-1185. 10.Weiran Chai, Rongxiang Wang, Xiaowei Wen, Haiyan Guo, Hui Long, Zheng Yan, Qifeng Lyu, Yanping Kuang, Songguo Xue*. Transfer of vitrified-warmed day 7 blastocysts following in vitro fertilization/intracytoplasmic sperm injection to Chinese women resulted in the successful delivery of nineteen healthy babies. Am J Clin Exp Obstet Gynecol 2016; 3(2):32-39. 11.Songguo Xue, Qiuping Peng, Qiao Yu, Qifeng Lyu, Shaofeng Cao, Yanping Kuang*, Sucrose pretreatment vitrification yields 接近满分 survival rate of mouse and human eggs, The 2nd World Congress on Fertility Preservation, USA, 2011.12.08-10, Journal of assisted reproduction and genetics, 28, 1002-1003. 12.Songguo Xue, Qiuping Peng, Shaofeng Cao, Qiao Yu, Jiqiang Si, Yanping Kuang*, Cryopreservation of a small number of human spermatozoa with home-made Strawtop: 3 years experience. The 2nd World Congress on Fertility Preservation, USA, 2011.12.08-10, Journal of assisted reproduction and genetics, 28, 991-992. 13.Qiu-Ping Peng, Shao-Feng Cao, Qi-Feng Lyu, Song-Guo Xue*, Wei Jin, Xiao-Yin Liu, Wen-Jie Zhang, H. Ingolf Nielsen, Yan-Ping Kuang. A novel method for cryopreservation of individual human spermatozoa. In Vitro Cellular & Developmental Biology - Animal. 2011, 47(8):565-72. 14.S. Xue, Q. Lyu, Q. Peng, S. Cao, Y. Zhou, Y. Kuang*, Vitrification yields superior efficiency of human cleavage-stage embryo cryopreservation versus slow-freezing, The 66th ASRM Annual Meeting, USA, 2010.10.23-27, P90, poster presentation. 15.X. Liu, S. Xue, W. Jin, et al. Impact of Incubation Time of Vitrification-warming Embryo on Frozen-thawed Embryo Transfer. Journal of Reproductive Medicine, 2010, 19:104-107. 16.S Xue, J. Yang, F. Yao, et al. Recurrent spontaneous abortions patients have more −14bp/+14bp heterozygotes in the 3′UT region of the HLA-G gene in a Chinese Han population. Tissue antigen. 2007, 69 Suppl 1: 153-155. 17.S. Xue, J. Yang, F. Yao, et al. Study on the polymorphism of the 14 bp deletion of HLA-G allele in patients with recurrent spontaneous abortion of unknown origin and normal deliveries. Current Immunology. 2006, 26(4): 318-321. 18.S. Xue, L. FAN. Construction and sequencing of eukaryotic expression vector of human LAIR-1-IgFc fusion protein gene. Immunological Journal. 2006, 22(3): 348-348.
获得课题：
1.国家自然科学基金面上项目（82171691），氧/ROS/DNA甲基化修饰调控轴对CryoClean新技术有效性和子代安全性的作用机制研究，2022-2025，主持。 2.国家自然科学基金面上项目（31572546），布鲁氏菌LuxS/AI-2型密度感应系统的构建及其调控机制研究，2016-2019，合作单位主持。 3.上海市市级医院新兴前沿技术联合攻关项目（SHDC12015122），无精子症生育力重建：精子获取与冻融前沿技术创立，2016-2018，合作单位主持。 4.上海市自然科学基金项目（09ZR1417000），人微量精子冻存及升降温相关的损伤机理研究，2009-2011，主持。
科研方向：
卵子冷冻 精子冷冻 胚胎冷冻
上海市医学会生殖医学分会青年委员
擅长：
临床胚胎学 （1）对受精失败、低受精率有丰富处理经验； （2）对反复胚胎差有丰富处理经验； （3）对卵子成熟障碍有丰富处理经验； （4）2007年开始推广胚胎玻璃化冷冻，2008-2010连续三年举办胚胎玻璃化冷冻培训班； （5）原创Cryopiece单精子冷冻（国内较前例单精子冷冻试管婴儿，2016），2017-2020连续四年举办单精子冷冻培训班。
发表文章：
第一或通讯作者（含共同第一或共同通讯） 1.Xu Y, Wang R, Pang Z, Wei Z, Sun L, Li S, Wang G, Liu Y, Zhou Y, Ye H, Jin L, Xue S. Novel Homozygous PADI6 Variants in Infertile Females with Early Embryonic Arrest[J]. Front Cell Dev Biol. 2022 Apr 1;10:819667. doi: 10.3389/fcell.2022.819667. eCollection 2022. 2.Yu K, Wang RX, Li MH, Sun TC, Zhou YW, Li YY, Sun LH, Zhang BL, Lian ZX, Xue SG, Liu YX, Deng SL. Melatonin Reduces Androgen Production and Upregulates Heme Oxygenase-1 Expression in Granulosa Cells from PCOS Patients with Hypoestrogenia and Hyperandrogenia[J]. Oxid Med Cell Longev. 2019 Oct 20;2019:8218650. doi: 10.1155/2019/8218650. eCollection 2019.PMID: 31772710 3.Sun L, Tian H, Xue S, Ye H, Xue X, Wang R, Liu Y, Zhang C, Chen Q, Gao S. Tie1 contributes to the development of ovarian hyperstimulation syndrome under the regulation of EGR1 in granulosa cells[J]. Exp Mol Med. 2022 Jan;54(1):81-90. doi: 10.1038/s12276-021-00722-8. Epub 2022 Jan 25.PMID: 35079118 4.Zhao, L#, Xue, S#, Yao, Z#. et al. Biallelic mutations in CDC20 cause female infertility characterized by abnormalities in oocyte maturation and early embryonic development. Protein Cell (2020). https://doi.org/10.1007/s13238-020-00756-0 5.中国男性生育力保存专家共识编写组（专家）. 中国男性生育力保存专家共识[J]. 中华生殖与避孕, 2021, 41(3):191-198 DOI: 10.3760/cma.j.cn101441-20200831-00469. 6.王荣祥,喻乔,彭秋平,曹少锋,张彩霞,刘宇,周怡雯,薛松果.自制冷冻片微型载体（Strawtop）微量精液冻存效果的实验研究[J].中华生殖与避孕杂志,2020,40(12):1006-1012.DOI:10.3760/cma.j.cn101441-20191014-00458. 7.Yao Xu, Ying Qian, Yu Liu, Qiaofeng Wang, Rongxiang Wang, Yiwen Zhou, Caixia Zhang, Zhi Pang, Hongjuan Ye, Songguo Xue*, Lihua Sun*. A novel homozygous variant in NLRP5 is associate with human early embryonic arrest in a consanguineous Chinese family. Clin Genet. 2020 Mar 29. doi: 10.1111/cge.13744. Online ahead of print. 8.Yu, Kun, Wang, Rong-Xiang, Li, Meng-Hui, Sun, Tie-Cheng, Zhou, Yi-Wen, Li, Yuan-Yuan, Sun, Li-Hua, Zhang, Bao-Lu, Lian, Zheng-Xing*, Xue, Song-Guo*, Liu, Yi-Xun, Deng, Shou-Long*. Melatonin Reduces Androgen Production and Upregulates Heme Oxygenase-1 Expression in Granulosa Cells from PCOS Patients , with Hypoestrogenia and Hyperandrogenia. Oxidative Medicine and Cellular Longevity, 2019 Oct 20;2019:8218650. doi: 10.1155/2019/8218650. eCollection 2019. 9.Yao Wang, Mei-lin Zhang, Lei-wen Zhao, Yan-ping Kuang, Song-guo Xue*. Enhancement of the efficiency of oocyte vitrification through regulation of histone deacetylase 6 expression. J Assist Reprod Genet. 2018 Jul; 35(7):1179-1185. 10.Weiran Chai, Rongxiang Wang, Xiaowei Wen, Haiyan Guo, Hui Long, Zheng Yan, Qifeng Lyu, Yanping Kuang, Songguo Xue*. Transfer of vitrified-warmed day 7 blastocysts following in vitro fertilization/intracytoplasmic sperm injection to Chinese women resulted in the successful delivery of nineteen healthy babies. Am J Clin Exp Obstet Gynecol 2016; 3(2):32-39. 11.Songguo Xue, Qiuping Peng, Qiao Yu, Qifeng Lyu, Shaofeng Cao, Yanping Kuang*, Sucrose pretreatment vitrification yields 接近满分 survival rate of mouse and human eggs, The 2nd World Congress on Fertility Preservation, USA, 2011.12.08-10, Journal of assisted reproduction and genetics, 28, 1002-1003. 12.Songguo Xue, Qiuping Peng, Shaofeng Cao, Qiao Yu, Jiqiang Si, Yanping Kuang*, Cryopreservation of a small number of human spermatozoa with home-made Strawtop: 3 years experience. The 2nd World Congress on Fertility Preservation, USA, 2011.12.08-10, Journal of assisted reproduction and genetics, 28, 991-992. 13.Qiu-Ping Peng, Shao-Feng Cao, Qi-Feng Lyu, Song-Guo Xue*, Wei Jin, Xiao-Yin Liu, Wen-Jie Zhang, H. Ingolf Nielsen, Yan-Ping Kuang. A novel method for cryopreservation of individual human spermatozoa. In Vitro Cellular & Developmental Biology - Animal. 2011, 47(8):565-72. 14.S. Xue, Q. Lyu, Q. Peng, S. Cao, Y. Zhou, Y. Kuang*, Vitrification yields superior efficiency of human cleavage-stage embryo cryopreservation versus slow-freezing, The 66th ASRM Annual Meeting, USA, 2010.10.23-27, P90, poster presentation. 15.X. Liu, S. Xue, W. Jin, et al. Impact of Incubation Time of Vitrification-warming Embryo on Frozen-thawed Embryo Transfer. Journal of Reproductive Medicine, 2010, 19:104-107. 16.S Xue, J. Yang, F. Yao, et al. Recurrent spontaneous abortions patients have more −14bp/+14bp heterozygotes in the 3′UT region of the HLA-G gene in a Chinese Han population. Tissue antigen. 2007, 69 Suppl 1: 153-155. 17.S. Xue, J. Yang, F. Yao, et al. Study on the polymorphism of the 14 bp deletion of HLA-G allele in patients with recurrent spontaneous abortion of unknown origin and normal deliveries. Current Immunology. 2006, 26(4): 318-321. 18.S. Xue, L. FAN. Construction and sequencing of eukaryotic expression vector of human LAIR-1-IgFc fusion protein gene. Immunological Journal. 2006, 22(3): 348-348.
获得课题：
1.国家自然科学基金面上项目（82171691），氧/ROS/DNA甲基化修饰调控轴对CryoClean新技术有效性和子代安全性的作用机制研究，2022-2025，主持。 2.国家自然科学基金面上项目（31572546），布鲁氏菌LuxS/AI-2型密度感应系统的构建及其调控机制研究，2016-2019，合作单位主持。 3.上海市市级医院新兴前沿技术联合攻关项目（SHDC12015122），无精子症生育力重建：精子获取与冻融前沿技术创立，2016-2018，合作单位主持。 4.上海市自然科学基金项目（09ZR1417000），人微量精子冻存及升降温相关的损伤机理研究，2009-2011，主持。
科研方向：
卵子冷冻 精子冷冻 胚胎冷冻
学术职务：
上海市医学会生殖医学分会青年委员
擅长：
临床胚胎学 （1）对受精失败、低受精率有丰富处理经验； （2）对反复胚胎差有丰富处理经验； （3）对卵子成熟障碍有丰富处理经验； （4）2007年开始推广胚胎玻璃化冷冻，2008-2010连续三年举办胚胎玻璃化冷冻培训班； （5）原创Cryopiece单精子冷冻（国内较前例单精子冷冻试管婴儿，2016），2017-2020连续四年举办单精子冷冻培训班。
发表文章：
第一或通讯作者（含共同第一或共同通讯） 1.Xu Y, Wang R, Pang Z, Wei Z, Sun L, Li S, Wang G, Liu Y, Zhou Y, Ye H, Jin L, Xue S. Novel Homozygous PADI6 Variants in Infertile Females with Early Embryonic Arrest[J]. Front Cell Dev Biol. 2022 Apr 1;10:819667. doi: 10.3389/fcell.2022.819667. eCollection 2022. 2.Yu K, Wang RX, Li MH, Sun TC, Zhou YW, Li YY, Sun LH, Zhang BL, Lian ZX, Xue SG, Liu YX, Deng SL. Melatonin Reduces Androgen Production and Upregulates Heme Oxygenase-1 Expression in Granulosa Cells from PCOS Patients with Hypoestrogenia and Hyperandrogenia[J]. Oxid Med Cell Longev. 2019 Oct 20;2019:8218650. doi: 10.1155/2019/8218650. eCollection 2019.PMID: 31772710 3.Sun L, Tian H, Xue S, Ye H, Xue X, Wang R, Liu Y, Zhang C, Chen Q, Gao S. Tie1 contributes to the development of ovarian hyperstimulation syndrome under the regulation of EGR1 in granulosa cells[J]. Exp Mol Med. 2022 Jan;54(1):81-90. doi: 10.1038/s12276-021-00722-8. Epub 2022 Jan 25.PMID: 35079118 4.Zhao, L#, Xue, S#, Yao, Z#. et al. Biallelic mutations in CDC20 cause female infertility characterized by abnormalities in oocyte maturation and early embryonic development. Protein Cell (2020). https://doi.org/10.1007/s13238-020-00756-0 5.中国男性生育力保存专家共识编写组（专家）. 中国男性生育力保存专家共识[J]. 中华生殖与避孕, 2021, 41(3):191-198 DOI: 10.3760/cma.j.cn101441-20200831-00469. 6.王荣祥,喻乔,彭秋平,曹少锋,张彩霞,刘宇,周怡雯,薛松果.自制冷冻片微型载体（Strawtop）微量精液冻存效果的实验研究[J].中华生殖与避孕杂志,2020,40(12):1006-1012.DOI:10.3760/cma.j.cn101441-20191014-00458. 7.Yao Xu, Ying Qian, Yu Liu, Qiaofeng Wang, Rongxiang Wang, Yiwen Zhou, Caixia Zhang, Zhi Pang, Hongjuan Ye, Songguo Xue*, Lihua Sun*. A novel homozygous variant in NLRP5 is associate with human early embryonic arrest in a consanguineous Chinese family. Clin Genet. 2020 Mar 29. doi: 10.1111/cge.13744. Online ahead of print. 8.Yu, Kun, Wang, Rong-Xiang, Li, Meng-Hui, Sun, Tie-Cheng, Zhou, Yi-Wen, Li, Yuan-Yuan, Sun, Li-Hua, Zhang, Bao-Lu, Lian, Zheng-Xing*, Xue, Song-Guo*, Liu, Yi-Xun, Deng, Shou-Long*. Melatonin Reduces Androgen Production and Upregulates Heme Oxygenase-1 Expression in Granulosa Cells from PCOS Patients , with Hypoestrogenia and Hyperandrogenia. Oxidative Medicine and Cellular Longevity, 2019 Oct 20;2019:8218650. doi: 10.1155/2019/8218650. eCollection 2019. 9.Yao Wang, Mei-lin Zhang, Lei-wen Zhao, Yan-ping Kuang, Song-guo Xue*. Enhancement of the efficiency of oocyte vitrification through regulation of histone deacetylase 6 expression. J Assist Reprod Genet. 2018 Jul; 35(7):1179-1185. 10.Weiran Chai, Rongxiang Wang, Xiaowei Wen, Haiyan Guo, Hui Long, Zheng Yan, Qifeng Lyu, Yanping Kuang, Songguo Xue*. Transfer of vitrified-warmed day 7 blastocysts following in vitro fertilization/intracytoplasmic sperm injection to Chinese women resulted in the successful delivery of nineteen healthy babies. Am J Clin Exp Obstet Gynecol 2016; 3(2):32-39. 11.Songguo Xue, Qiuping Peng, Qiao Yu, Qifeng Lyu, Shaofeng Cao, Yanping Kuang*, Sucrose pretreatment vitrification yields 接近满分 survival rate of mouse and human eggs, The 2nd World Congress on Fertility Preservation, USA, 2011.12.08-10, Journal of assisted reproduction and genetics, 28, 1002-1003. 12.Songguo Xue, Qiuping Peng, Shaofeng Cao, Qiao Yu, Jiqiang Si, Yanping Kuang*, Cryopreservation of a small number of human spermatozoa with home-made Strawtop: 3 years experience. The 2nd World Congress on Fertility Preservation, USA, 2011.12.08-10, Journal of assisted reproduction and genetics, 28, 991-992. 13.Qiu-Ping Peng, Shao-Feng Cao, Qi-Feng Lyu, Song-Guo Xue*, Wei Jin, Xiao-Yin Liu, Wen-Jie Zhang, H. Ingolf Nielsen, Yan-Ping Kuang. A novel method for cryopreservation of individual human spermatozoa. In Vitro Cellular & Developmental Biology - Animal. 2011, 47(8):565-72. 14.S. Xue, Q. Lyu, Q. Peng, S. Cao, Y. Zhou, Y. Kuang*, Vitrification yields superior efficiency of human cleavage-stage embryo cryopreservation versus slow-freezing, The 66th ASRM Annual Meeting, USA, 2010.10.23-27, P90, poster presentation. 15.X. Liu, S. Xue, W. Jin, et al. Impact of Incubation Time of Vitrification-warming Embryo on Frozen-thawed Embryo Transfer. Journal of Reproductive Medicine, 2010, 19:104-107. 16.S Xue, J. Yang, F. Yao, et al. Recurrent spontaneous abortions patients have more −14bp/+14bp heterozygotes in the 3′UT region of the HLA-G gene in a Chinese Han population. Tissue antigen. 2007, 69 Suppl 1: 153-155. 17.S. Xue, J. Yang, F. Yao, et al. Study on the polymorphism of the 14 bp deletion of HLA-G allele in patients with recurrent spontaneous abortion of unknown origin and normal deliveries. Current Immunology. 2006, 26(4): 318-321. 18.S. Xue, L. FAN. Construction and sequencing of eukaryotic expression vector of human LAIR-1-IgFc fusion protein gene. Immunological Journal. 2006, 22(3): 348-348.
获得课题：
1.国家自然科学基金面上项目（82171691），氧/ROS/DNA甲基化修饰调控轴对CryoClean新技术有效性和子代安全性的作用机制研究，2022-2025，主持。 2.国家自然科学基金面上项目（31572546），布鲁氏菌LuxS/AI-2型密度感应系统的构建及其调控机制研究，2016-2019，合作单位主持。 3.上海市市级医院新兴前沿技术联合攻关项目（SHDC12015122），无精子症生育力重建：精子获取与冻融前沿技术创立，2016-2018，合作单位主持。 4.上海市自然科学基金项目（09ZR1417000），人微量精子冻存及升降温相关的损伤机理研究，2009-2011，主持。
科研方向：
卵子冷冻 精子冷冻 胚胎冷冻
上海市医学会生殖医学分会青年委员
擅长：
临床胚胎学 （1）对受精失败、低受精率有丰富处理经验； （2）对反复胚胎差有丰富处理经验； （3）对卵子成熟障碍有丰富处理经验； （4）2007年开始推广胚胎玻璃化冷冻，2008-2010连续三年举办胚胎玻璃化冷冻培训班； （5）原创Cryopiece单精子冷冻（国内较前例单精子冷冻试管婴儿，2016），2017-2020连续四年举办单精子冷冻培训班。
发表文章：
第一或通讯作者（含共同第一或共同通讯） 1.Xu Y, Wang R, Pang Z, Wei Z, Sun L, Li S, Wang G, Liu Y, Zhou Y, Ye H, Jin L, Xue S. Novel Homozygous PADI6 Variants in Infertile Females with Early Embryonic Arrest[J]. Front Cell Dev Biol. 2022 Apr 1;10:819667. doi: 10.3389/fcell.2022.819667. eCollection 2022. 2.Yu K, Wang RX, Li MH, Sun TC, Zhou YW, Li YY, Sun LH, Zhang BL, Lian ZX, Xue SG, Liu YX, Deng SL. Melatonin Reduces Androgen Production and Upregulates Heme Oxygenase-1 Expression in Granulosa Cells from PCOS Patients with Hypoestrogenia and Hyperandrogenia[J]. Oxid Med Cell Longev. 2019 Oct 20;2019:8218650. doi: 10.1155/2019/8218650. eCollection 2019.PMID: 31772710 3.Sun L, Tian H, Xue S, Ye H, Xue X, Wang R, Liu Y, Zhang C, Chen Q, Gao S. Tie1 contributes to the development of ovarian hyperstimulation syndrome under the regulation of EGR1 in granulosa cells[J]. Exp Mol Med. 2022 Jan;54(1):81-90. doi: 10.1038/s12276-021-00722-8. Epub 2022 Jan 25.PMID: 35079118 4.Zhao, L#, Xue, S#, Yao, Z#. et al. Biallelic mutations in CDC20 cause female infertility characterized by abnormalities in oocyte maturation and early embryonic development. Protein Cell (2020). https://doi.org/10.1007/s13238-020-00756-0 5.中国男性生育力保存专家共识编写组（专家）. 中国男性生育力保存专家共识[J]. 中华生殖与避孕, 2021, 41(3):191-198 DOI: 10.3760/cma.j.cn101441-20200831-00469. 6.王荣祥,喻乔,彭秋平,曹少锋,张彩霞,刘宇,周怡雯,薛松果.自制冷冻片微型载体（Strawtop）微量精液冻存效果的实验研究[J].中华生殖与避孕杂志,2020,40(12):1006-1012.DOI:10.3760/cma.j.cn101441-20191014-00458. 7.Yao Xu, Ying Qian, Yu Liu, Qiaofeng Wang, Rongxiang Wang, Yiwen Zhou, Caixia Zhang, Zhi Pang, Hongjuan Ye, Songguo Xue*, Lihua Sun*. A novel homozygous variant in NLRP5 is associate with human early embryonic arrest in a consanguineous Chinese family. Clin Genet. 2020 Mar 29. doi: 10.1111/cge.13744. Online ahead of print. 8.Yu, Kun, Wang, Rong-Xiang, Li, Meng-Hui, Sun, Tie-Cheng, Zhou, Yi-Wen, Li, Yuan-Yuan, Sun, Li-Hua, Zhang, Bao-Lu, Lian, Zheng-Xing*, Xue, Song-Guo*, Liu, Yi-Xun, Deng, Shou-Long*. Melatonin Reduces Androgen Production and Upregulates Heme Oxygenase-1 Expression in Granulosa Cells from PCOS Patients , with Hypoestrogenia and Hyperandrogenia. Oxidative Medicine and Cellular Longevity, 2019 Oct 20;2019:8218650. doi: 10.1155/2019/8218650. eCollection 2019. 9.Yao Wang, Mei-lin Zhang, Lei-wen Zhao, Yan-ping Kuang, Song-guo Xue*. Enhancement of the efficiency of oocyte vitrification through regulation of histone deacetylase 6 expression. J Assist Reprod Genet. 2018 Jul; 35(7):1179-1185. 10.Weiran Chai, Rongxiang Wang, Xiaowei Wen, Haiyan Guo, Hui Long, Zheng Yan, Qifeng Lyu, Yanping Kuang, Songguo Xue*. Transfer of vitrified-warmed day 7 blastocysts following in vitro fertilization/intracytoplasmic sperm injection to Chinese women resulted in the successful delivery of nineteen healthy babies. Am J Clin Exp Obstet Gynecol 2016; 3(2):32-39. 11.Songguo Xue, Qiuping Peng, Qiao Yu, Qifeng Lyu, Shaofeng Cao, Yanping Kuang*, Sucrose pretreatment vitrification yields 接近满分 survival rate of mouse and human eggs, The 2nd World Congress on Fertility Preservation, USA, 2011.12.08-10, Journal of assisted reproduction and genetics, 28, 1002-1003. 12.Songguo Xue, Qiuping Peng, Shaofeng Cao, Qiao Yu, Jiqiang Si, Yanping Kuang*, Cryopreservation of a small number of human spermatozoa with home-made Strawtop: 3 years experience. The 2nd World Congress on Fertility Preservation, USA, 2011.12.08-10, Journal of assisted reproduction and genetics, 28, 991-992. 13.Qiu-Ping Peng, Shao-Feng Cao, Qi-Feng Lyu, Song-Guo Xue*, Wei Jin, Xiao-Yin Liu, Wen-Jie Zhang, H. Ingolf Nielsen, Yan-Ping Kuang. A novel method for cryopreservation of individual human spermatozoa. In Vitro Cellular & Developmental Biology - Animal. 2011, 47(8):565-72. 14.S. Xue, Q. Lyu, Q. Peng, S. Cao, Y. Zhou, Y. Kuang*, Vitrification yields superior efficiency of human cleavage-stage embryo cryopreservation versus slow-freezing, The 66th ASRM Annual Meeting, USA, 2010.10.23-27, P90, poster presentation. 15.X. Liu, S. Xue, W. Jin, et al. Impact of Incubation Time of Vitrification-warming Embryo on Frozen-thawed Embryo Transfer. Journal of Reproductive Medicine, 2010, 19:104-107. 16.S Xue, J. Yang, F. Yao, et al. Recurrent spontaneous abortions patients have more −14bp/+14bp heterozygotes in the 3′UT region of the HLA-G gene in a Chinese Han population. Tissue antigen. 2007, 69 Suppl 1: 153-155. 17.S. Xue, J. Yang, F. Yao, et al. Study on the polymorphism of the 14 bp deletion of HLA-G allele in patients with recurrent spontaneous abortion of unknown origin and normal deliveries. Current Immunology. 2006, 26(4): 318-321. 18.S. Xue, L. FAN. Construction and sequencing of eukaryotic expression vector of human LAIR-1-IgFc fusion protein gene. Immunological Journal. 2006, 22(3): 348-348.
获得课题：
1.国家自然科学基金面上项目（82171691），氧/ROS/DNA甲基化修饰调控轴对CryoClean新技术有效性和子代安全性的作用机制研究，2022-2025，主持。 2.国家自然科学基金面上项目（31572546），布鲁氏菌LuxS/AI-2型密度感应系统的构建及其调控机制研究，2016-2019，合作单位主持。 3.上海市市级医院新兴前沿技术联合攻关项目（SHDC12015122），无精子症生育力重建：精子获取与冻融前沿技术创立，2016-2018，合作单位主持。 4.上海市自然科学基金项目（09ZR1417000），人微量精子冻存及升降温相关的损伤机理研究，2009-2011，主持。
科研方向：
卵子冷冻 精子冷冻 胚胎冷冻
专业擅长:
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