张兆旭

张兆旭，男，北京大学人民医院神经内科，神经病学博士学位，副主任医师。长期从事神经系统疾病的临床诊治和科学研究。擅长老年性痴呆、脑血管病、帕金森病、重症肌无力、炎性脱髓鞘、中枢神经系统感染、神经系统变性病及遗传代谢性疾病，尤其擅长各种疑难神经系统疾病诊治。 担任神经担任中国老年医学会心脑血管病分会委员、中国卒中学会血管认知障碍委员会委员、中华预防医学会慢性疾病学会委员、中国阿尔茨海默病防治协会委员、北京医学会心脏心理学会委员、北京市神经病学会理事、国家卫健委脑卒中防治工程青年专家委员会委员。 主持国家自然科学基金及省部级课题3项，参与澳大利亚-中国合作项目《急性脑梗死半暗带的抢救》多项课题4项；以第一（通讯）作者发表国内外期刊论文30篇，其中SCI收录16篇；主编专著《痴呆诊疗和预防》人民卫生出版社（55万字）、参编专著《血管性痴呆》、《阿尔茨海默病的诊断与治疗》；“敷贴式局部亚低温治疗急性大面积脑梗死”获得教育部科技进步一等奖1项（第三）。

1. Zhang, Z.;Bi, M.; Tong, S.;;Ma, Q.; Zhang, S.; Luo, Z.; Zhang, Y.; Li, X.; Wang, D., Changes in cerebral glucose metabolism in patients with mild-to-moderate Alzheimer's disease: a pilot study with the Chinese herbal medicine fuzhisan. Neurosci Lett 2011, 501 (1), 35-40. 2.Zhang ZX, Zhao RP, Wang DS, Li YB.Fuzhisan Ameliorates the Memory Deficits in Aged SAMP8 Mice via Decreasing Aβ Production and Tau Hyperphosphorylation of the Hippocampus. Neurochem Res. 2016 Nov;41(11):3074-3082. 3.Zhang ZX, Zhao RP, Wang DS, Wang AN.Fuzhisan ameliorates Aβ production and tau phosphorylation in hippocampal of 11month old APP/PS1 transgenic mice: A Western blot study.Exp Gerontol. 2016 Nov;84:88-95. 4.Zhang, Z.; Zhao, R.; Qi, J.; Wen, S.; Tang, Y.; Wang, D., Inhibition of glycogen synthase kinase-3beta by Angelica sinensis extract decreases beta-amyloid-induced neurotoxicity and tau phosphorylation in cultured cortical neurons. J Neurosci Res 2011, 89 (3), 437-47. 5. Zhang, Z.; Zhao, R.; Song, Y.; Wang, D.; Qi, J.; Wen, S., Implication of phosphatidylinositol-3 kinase/Akt/glycogen synthase kinase-3beta pathway in ginsenoside Rb1's attenuation of beta-amyloid-induced neurotoxicity and tau phosphorylation. J Ethnopharmacol 2011, 133 (3), 1109-16. 6.Zhang, Z.; Zhao, R.; Tang, Y.; Wen, S.; Wang, D.; Qi, J., Fuzhisan, a Chinese herbal medicine, inhibits beta-amyloid-induced neurotoxicity and tau phosphorylation through calpain/Cdk5 pathway in cultured cortical neurons. Neurochem Res 2011, 36 (5), 801-11. 7.Zhang ZX, Li YB, Zhao RP.Epigallocatechin Gallate Attenuates β-Amyloid Generation and Oxidative Stress Involvement of PPARγ in N2a/APP695 Cells.Neurochem Res. 2017 Feb;42(2):468-480. 8.《痴呆诊疗及预防》（55万字），人民卫生出版社，2016年，主编。