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所在医院：四川大学华西第二医院三级甲等

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展开 1.职称：研究员2.学历：博士3.研究方向：主要研究肿瘤微环境如何诱导和维持肿瘤干细胞。我们认为肿瘤的血管微环境，特别是血管内皮细胞，通过分泌旁分泌因子来调控肿瘤干细胞的生长，迁移，化疗抗性等属性。这些发现从概念上改变了血管系统在肿瘤和纤维化中传输血液的传统观点。对血管微环境与肿瘤干细胞相互作用的系统研究加深了目前对肿瘤和纤维化病理机制的理解。所得的理论发现可用来设计特异性针对肿瘤和纤维化组织中畸变血管微环境的治疗手段，具有很强的应用价值。4.邮件：zhongweicao@hotmail.com5.教育经历：南京大学学士，硕士，加州大学戴维斯分校博士，斯坦福大学，康奈尔大学博士后，讲师6.代表性论文（1）.CaoZ,LisR,GinsbergM,ChavezD,ShidoK,RabbanySY,FongGH,SakmarTP,RafiiS,DingBS.Targetingofthepulmonarycapillaryvascularnichepromoteslungalveolarreparirandamelioratesfibrosis.NatMed2016,22(2):154-62.PMID26779814（2）.CaoZ,DingBS,GuoP,LeeSL,ButlerJM,CaseySC,SimonsM,TamW,FelsherDW,ShidoK,ScanduraJM,RafiiS.AngiocrinesignalsfromtumorvascularnicheinduceB-Celllymphomainvasivenessandchemoresistance.CancerCell2014,25(3):1-16.PMID24651014Highlightedin1)CancerCell2014,25(3),261–263;2)NatureReviewsCancer14,298(2014)doi:10.1038/nrc3730;3)ScienceSignaling2014,7(319):p.ec85.（3）.CaoZ#,DingBS#,LisR,NolanDJ,GuoP,SimonsM,PenfoldM,ShidoK,RabbanySY,andRafii,S.Divergentangiocrinesignalsfromvascularnichebalanceliverregenerationandfibrosis.Nature,505(7481):97-102,2014(Epub2013Nov20)(#equalcontribution).PMID24256728Highlightedin1)ScienceSignaling2014,7(307):ec7;2)F1000Prime(article718183961);3)ScienceTranslationalMedicine2014,6(224):ec33.4)Hepatology2014,doi:10.1002/hep.27116.（4）.RafiiS,CaoZ,LisR,ChavezD,ShidoK,RabbanySY,DingBS.Platelet-derivedSDF-1primesthepulmonarycapillaryvascularnichetodrivelungalveolarregeneration.NatureCellBiology2015,17(2):123-36.PMID25621952（5）.CaoZ,Fan-MinogueH,BellovinDI,Yevtodiyenko,ArzenoJ,YangQ,GambhirSS,FelsherDW.MYCphosphorylation,activation,andtumorigenicpotentialinhepatocellularcarcinomaareregulatedbyHMG-CoAreductase.CancerRes.2011,71(6):2286-97.PMID21262914（6）.DingBS,NolanDJ,GuoP,BabazadehAO,CaoZ,RosenwaksZ,CrystalRG,SimonsM,SatoTN,WorgallS,ShidoK,RabbanySY,RafiiS.Endothelial-derivedangiocrinesignalsinduceandsustainregenerativelungalveolarization.Cell.2011,147(3):539-53.PMID22036563（7）.Fan-MinogueH,CaoZ,PaulmuruganR,ChanCT,MassoudTF,FelsherDW,GambhirSS.Noninvasivemolecularimagingofc-MYCactivationinlivingmice.ProcNatlAcadSciUSA.2010,107(36):15892-7.PMID20713710（8）.CaoZ,WuX,YenL,SweeneyC,CarrawayKL3rd.Neuregulin-inducedErbB3downregulationismediatedbyaproteinstabilitycascadeinvolvingtheE3ubiquitinligaseNrdp1.MolCellBiol.2007,27(6):3280-8.PMID17210635（9）.YenL,CaoZ,WuX,InjallaER,BaronC,YoungLJ,GreggJP,CardiffRD,BorowskyAD,SweeneyC,CarrawayKL3rd.LossofNrdp1enhancesErbB2/ErbB3-dependentbreasttumorcellgrowth.CancerRes.2006,66(23):11279-86.PMID17145873（10).BallifBA,CaoZ,SchwartzD,CarrawayKL3rd,GygiSP.Identificationof14-3-3epsilonsubstratesfromembryonicmurinebrain.JProteomeRes.2006,5(9):2372-9PMID16944949

1.职称：研究员2.学历：博士3.研究方向：主要研究肿瘤微环境如何诱导和维持肿瘤干细胞。我们认为肿瘤的血管微环境，特别是血管内皮细胞，通过分泌旁分泌因子来调控肿瘤干细胞的生长，迁移，化疗抗性等属性。这些发现从概念上改变了血管系统在肿瘤和纤维化中传输血液的传统观点。对血管微环境与肿瘤干细胞相互作用的系统研究加深了目前对肿瘤和纤维化病理机制的理解。所得的理论发现可用来设计特异性针对肿瘤和纤维化组织中畸变血管微环境的治疗手段，具有很强的应用价值。4.邮件：zhongweicao@hotmail.com5.教育经历：南京大学学士，硕士，加州大学戴维斯分校博士，斯坦福大学，康奈尔大学博士后，讲师6.代表性论文（1）.CaoZ,LisR,GinsbergM,ChavezD,ShidoK,RabbanySY,FongGH,SakmarTP,RafiiS,DingBS.Targetingofthepulmonarycapillaryvascularnichepromoteslungalveolarreparirandamelioratesfibrosis.NatMed2016,22(2):154-62.PMID26779814（2）.CaoZ,DingBS,GuoP,LeeSL,ButlerJM,CaseySC,SimonsM,TamW,FelsherDW,ShidoK,ScanduraJM,RafiiS.AngiocrinesignalsfromtumorvascularnicheinduceB-Celllymphomainvasivenessandchemoresistance.CancerCell2014,25(3):1-16.PMID24651014Highlightedin1)CancerCell2014,25(3),261–263;2)NatureReviewsCancer14,298(2014)doi:10.1038/nrc3730;3)ScienceSignaling2014,7(319):p.ec85.（3）.CaoZ#,DingBS#,LisR,NolanDJ,GuoP,SimonsM,PenfoldM,ShidoK,RabbanySY,andRafii,S.Divergentangiocrinesignalsfromvascularnichebalanceliverregenerationandfibrosis.Nature,505(7481):97-102,2014(Epub2013Nov20)(#equalcontribution).PMID24256728Highlightedin1)ScienceSignaling2014,7(307):ec7;2)F1000Prime(article718183961);3)ScienceTranslationalMedicine2014,6(224):ec33.4)Hepatology2014,doi:10.1002/hep.27116.（4）.RafiiS,CaoZ,LisR,ChavezD,ShidoK,RabbanySY,DingBS.Platelet-derivedSDF-1primesthepulmonarycapillaryvascularnichetodrivelungalveolarregeneration.NatureCellBiology2015,17(2):123-36.PMID25621952（5）.CaoZ,Fan-MinogueH,BellovinDI,Yevtodiyenko,ArzenoJ,YangQ,GambhirSS,FelsherDW.MYCphosphorylation,activation,andtumorigenicpotentialinhepatocellularcarcinomaareregulatedbyHMG-CoAreductase.CancerRes.2011,71(6):2286-97.PMID21262914（6）.DingBS,NolanDJ,GuoP,BabazadehAO,CaoZ,RosenwaksZ,CrystalRG,SimonsM,SatoTN,WorgallS,ShidoK,RabbanySY,RafiiS.Endothelial-derivedangiocrinesignalsinduceandsustainregenerativelungalveolarization.Cell.2011,147(3):539-53.PMID22036563（7）.Fan-MinogueH,CaoZ,PaulmuruganR,ChanCT,MassoudTF,FelsherDW,GambhirSS.Noninvasivemolecularimagingofc-MYCactivationinlivingmice.ProcNatlAcadSciUSA.2010,107(36):15892-7.PMID20713710（8）.CaoZ,WuX,YenL,SweeneyC,CarrawayKL3rd.Neuregulin-inducedErbB3downregulationismediatedbyaproteinstabilitycascadeinvolvingtheE3ubiquitinligaseNrdp1.MolCellBiol.2007,27(6):3280-8.PMID17210635（9）.YenL,CaoZ,WuX,InjallaER,BaronC,YoungLJ,GreggJP,CardiffRD,BorowskyAD,SweeneyC,CarrawayKL3rd.LossofNrdp1enhancesErbB2/ErbB3-dependentbreasttumorcellgrowth.CancerRes.2006,66(23):11279-86.PMID17145873（10).BallifBA,CaoZ,SchwartzD,CarrawayKL3rd,GygiSP.Identificationof14-3-3epsilonsubstratesfromembryonicmurinebrain.JProteomeRes.2006,5(9):2372-9PMID16944949

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