张志新

所在医院：四川大学华西第二医院三级甲等

所在科室：

医生简介:

展开 1.学历：博士2.Email:JasonZhang2011@hotmail.com3.研究方向：B淋巴细胞发育和抗体产生的分子调控细胞核骨架和B淋巴细胞基因表达以及免疫球蛋白基因重组自身免疫疾病中，诸如红斑狼疮和风湿性关节炎，B淋巴细胞的异常功能B淋巴细胞抗病毒反应B淋巴瘤和白血病的发病机理抗肿瘤抗体，免疫细胞治疗4.教育经历1985-1989学士/B.S.南开大学1989-1992硕士/M.S.南开大学1993-1997博士/Ph.D.美国阿拉巴马大学伯明翰分校1997-2003博士后美国阿拉巴马大学伯明翰分校，MaxCooper实验室5.工作经历2015-四川大学华西第二医院，教授，免疫发育和疾病治疗实验室PI2013-终身教授，美国内布拉斯加大学医学中心病理和微生物系2011-2013终身副教授，美国内布拉斯加大学医学中心病理和微生物系2008-2011副教授，美国内布拉斯加大学医学中心病理和微生物系2003-2008助理教授，美国阿拉巴马大学伯明翰分校6.代表性论文：（1）Rogosch,T,KerzelS,DeyF,Wagner,J-J,ZhangZ,MaierRF,andZemlinM.IgG4andIgEtranscriptsinchildhoodallergicasthmareflectdivergentantigen-drivenselection.JImmunol,193:5801-5808,2014.（2）LangeMD,HuangL,YuY,LiS,LiaoH,ZemlinM,SuK,andZhangZ*.AccumulationofVHReplacementProductsinIgHGenesDerivedfromAutoimmuneDiseasesandAnti-ViralResponsesinHuman,FrontImmunol.5:345,2014.（3）ZhangB,LiangJ,ZhangZ*,Roleofbiomarkersinmanagementofcomplicationsaftercardiacsurgery.JCardiovascSurg(Torino).55:1-2,2014.（4）HuangL,LangeMD,andZhangZ*.VHreplacementfootprintanalyser-I(VHRFA-I),aJavabasedcomputerprogramforanalysesofimmunoglobulinheavychaingenesandpotentialVHreplacementproductsinhumanandmouse.Front.Immunol.5:40,2014.（5）ShiG,ZhangJ,ZhangZ,ZhangX,Systemicautoimmunediseases.ClinDevImmunol,2013:728574,2013（6）LiS,YuY,YueY,ZhangZ,SuK,Microbialinfectionandrheumatoidarthritis.JClinCellImmunol,4:174,2013.（7）LiS,YuY,KoehnCD,ZhangZ,SuK,GalectinsinthePathogenesisofRheumatoidArthritis.JClinCellImmunol,4:164,2013.（8）LiuJ,XieW,LangeM,HongSY,SuK,andZhangZ*,InternalizationofBcellreceptors(BCRs)inhumanEU12muHC+immatureBcellsspecificallyaltersdownstreamsignalingevents.BioMedResInternational,2013:807240,2013.（9）HuangX,HuangL,PengH,GuruA,XueW,HongSY,LiuM,SharmaS,FuK,CaprezAP,SwansonDR,ZhangZ,andDingS-H,ISPTM:Aniterativesearchalgorithmforsystematicidentificationofpost-translationalmodificationsfromcomplexproteomemixtures.JProteomeRes,12:3831−3842,2013.（10）LiuJ,LangeM,HongSY,XieW,HuangL,EhrhardtG,BurrowsPD,SuK,CarterR,andZhangZ*,RegulationofVHreplacementbyBcellreceptor(BCR)-mediatedsignalinginhumanimmatureBcells.J.Immunol.190:5559-5566,2013.（11）HuangL,LangeMD,YuY,LiS,SuK,andZhangZ*.ContributionofVHreplacementproductsinmouseantibodyrepertoire.PLoSOne,8:e57877,2013.（12）LiaoH,RunF,LiuJ,LangeM,SuK,andZhangZ*,ContributionofVHreplacementproductstothegenerationofanti-HIVantibodies.ClinicalImmunol,146:46-55,2013.（13）HeT,HongSY,HuangL,XueW,YuZ,KwonH,KirkM,DingSJ,SuK,ZhangZ*.Histoneacetyltransferasep300acetylatesPax5andstronglyenhancesPax5-mediatedtranscriptionalactivity.JBiolChem.286:14137-14145.2011.

1.学历：博士2.Email:JasonZhang2011@hotmail.com3.研究方向：B淋巴细胞发育和抗体产生的分子调控细胞核骨架和B淋巴细胞基因表达以及免疫球蛋白基因重组自身免疫疾病中，诸如红斑狼疮和风湿性关节炎，B淋巴细胞的异常功能B淋巴细胞抗病毒反应B淋巴瘤和白血病的发病机理抗肿瘤抗体，免疫细胞治疗4.教育经历1985-1989学士/B.S.南开大学1989-1992硕士/M.S.南开大学1993-1997博士/Ph.D.美国阿拉巴马大学伯明翰分校1997-2003博士后美国阿拉巴马大学伯明翰分校，MaxCooper实验室5.工作经历2015-四川大学华西第二医院，教授，免疫发育和疾病治疗实验室PI2013-终身教授，美国内布拉斯加大学医学中心病理和微生物系2011-2013终身副教授，美国内布拉斯加大学医学中心病理和微生物系2008-2011副教授，美国内布拉斯加大学医学中心病理和微生物系2003-2008助理教授，美国阿拉巴马大学伯明翰分校6.代表性论文：（1）Rogosch,T,KerzelS,DeyF,Wagner,J-J,ZhangZ,MaierRF,andZemlinM.IgG4andIgEtranscriptsinchildhoodallergicasthmareflectdivergentantigen-drivenselection.JImmunol,193:5801-5808,2014.（2）LangeMD,HuangL,YuY,LiS,LiaoH,ZemlinM,SuK,andZhangZ*.AccumulationofVHReplacementProductsinIgHGenesDerivedfromAutoimmuneDiseasesandAnti-ViralResponsesinHuman,FrontImmunol.5:345,2014.（3）ZhangB,LiangJ,ZhangZ*,Roleofbiomarkersinmanagementofcomplicationsaftercardiacsurgery.JCardiovascSurg(Torino).55:1-2,2014.（4）HuangL,LangeMD,andZhangZ*.VHreplacementfootprintanalyser-I(VHRFA-I),aJavabasedcomputerprogramforanalysesofimmunoglobulinheavychaingenesandpotentialVHreplacementproductsinhumanandmouse.Front.Immunol.5:40,2014.（5）ShiG,ZhangJ,ZhangZ,ZhangX,Systemicautoimmunediseases.ClinDevImmunol,2013:728574,2013（6）LiS,YuY,YueY,ZhangZ,SuK,Microbialinfectionandrheumatoidarthritis.JClinCellImmunol,4:174,2013.（7）LiS,YuY,KoehnCD,ZhangZ,SuK,GalectinsinthePathogenesisofRheumatoidArthritis.JClinCellImmunol,4:164,2013.（8）LiuJ,XieW,LangeM,HongSY,SuK,andZhangZ*,InternalizationofBcellreceptors(BCRs)inhumanEU12muHC+immatureBcellsspecificallyaltersdownstreamsignalingevents.BioMedResInternational,2013:807240,2013.（9）HuangX,HuangL,PengH,GuruA,XueW,HongSY,LiuM,SharmaS,FuK,CaprezAP,SwansonDR,ZhangZ,andDingS-H,ISPTM:Aniterativesearchalgorithmforsystematicidentificationofpost-translationalmodificationsfromcomplexproteomemixtures.JProteomeRes,12:3831−3842,2013.（10）LiuJ,LangeM,HongSY,XieW,HuangL,EhrhardtG,BurrowsPD,SuK,CarterR,andZhangZ*,RegulationofVHreplacementbyBcellreceptor(BCR)-mediatedsignalinginhumanimmatureBcells.J.Immunol.190:5559-5566,2013.（11）HuangL,LangeMD,YuY,LiS,SuK,andZhangZ*.ContributionofVHreplacementproductsinmouseantibodyrepertoire.PLoSOne,8:e57877,2013.（12）LiaoH,RunF,LiuJ,LangeM,SuK,andZhangZ*,ContributionofVHreplacementproductstothegenerationofanti-HIVantibodies.ClinicalImmunol,146:46-55,2013.（13）HeT,HongSY,HuangL,XueW,YuZ,KwonH,KirkM,DingSJ,SuK,ZhangZ*.Histoneacetyltransferasep300acetylatesPax5andstronglyenhancesPax5-mediatedtranscriptionalactivity.JBiolChem.286:14137-14145.2011.

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