林静雯

所在医院：四川大学华西第二医院三级甲等

所在科室：

医生简介:

展开 1.职称：研究员2.学历：博士3.研究方向：运用系统免疫学方法研究机体对包括疟疾在内传染病的反应；利用系统生物学手段及基因修饰技术研究筛选新药、疫苗靶点。4.邮箱：lin.jingwen@scu.edu.cn5.个人经历2016年12月－至今，四川大学华西第二医院研究员2013年3月－2016年10月，UKMedicalResearchCouncilCareerDevelopmentFellow，TheFrancisCrickInstitute(原NationalInstituteforMedicalResearch)，英国2008年10月－2013年2月，博士，LeidenUniversityMedicalCenter，荷兰6.代表论文：(1)LinJW*,SodenkampJ,CunninghamD,etal,LanghorneJ*(2017).Signaturesofmalaria-associatedpathologyrevealedbyhigh-resolutionwhole-bloodtranscriptomicsinarodentmodelofmalaria.SciRep.(co-correspondingauthors).(2)BrugatT,ReidAJ,LinJW,etal(2016).Antibody-independentclonalselectionregulatestheestablishmentofchronicPlasmodiuminfection.NatureMicrobiology.(3)CapucciniB,LinJ,Talavera-LópezC,etal(2016).Transcriptomicprofilingofmicrogliarevealssignaturesofcellactivationandimmuneresponse,duringexperimentalcerebralmalaria.SciRep.(4)LinJW,SpaccapeloR,SchwarzerE,etal(2015).ReplicationofPlasmodiuminreticulocytescanoccurwithouthemozoinformation,resultinginchloroquineresistance.JExpMed.(5)SalmanAM,MogollonCM,LinJW,etal(2015).Generationoftransgenicrodentmalariaparasitesexpressinghuman-malariaparasiteproteins.MethodsMolBiol.(6)LinJW,ShawTN,BouchierP,etal(2014)ThesubcellularlocationofovalbumininPlasmodiumbergheibloodstagesinfluencesthemagnitudeofT-cellresponses.InfectImmun.(7)EzougouCN,Ben-RachedF,MossDK,LinJW,etal(2014)PlasmodiumfalciparumRab5BisN-terminallymyristoylatedandtargetedtotheparasite’splasmaandfoodvacuolemembranes.PLoSOne.(8)LinJW,MeirelesP,PrudêncioM,etal(2013)Loss-of-functionanalysesdefinesvitalandredundantfunctionsoftheplasmodiumrhomboidproteasefamily.MolecularMicrobiology.(9)AnnouraT,vanSchaijkBCL,PloemenIHJ,SajidM,LinJW,etal(2013)NewmembersofthePlasmodium6-Cysfamilyhavedistinctandcriticalrolesinliverstagedevelopment.FASEBJ(10)DeroostK,TybergheinA,LaysN,NoppenS,SchwarzerE,VanstreelsE,KomutaM,PratoM,LinJW,etal(2013)Hemozoininduceslunginflammationandcorrelateswithmalaria-associatedacuterespiratorydistresssyndrome.AmJRespirCellMolBiol(11)LinJW,SajidM,RamesarJ,KhanSM,JanseCJ,Franke-FayardB.(2011).ScreeninginhibitorsofP.bergheibloodstagesusingbioluminescentreporterparasites.MethodsMolBiol.(12)LinJW,AnnouraT,SajidM,Chevalley-MaurelS,RamesarJ,KlopO,Franke-FayardB,JanseCJ,KhanSM(2011)Anovel‘geneinsertion/markerout’(GIMO)methodfortransgeneex-x-pressionandgenecomplementationinrodentmalariaparasites.PLoSOne.(13)BaluB,MaherSP,PanceA,ChauhanC,NaumovAV,AndrewsRM,EllisPD,KhanSM,LinJW,etal(2011)CCR4-associatedfactor1coordinatestheex-x-pressionofPlasmodiumfalciparumegressandinvasionproteins.EukaryotCell.(14)BarkerRHJr,UrgaonkarS,MazitschekR,CelatkaC,SkerljR,CorteseJF,TyndallE,LiuH,CromwellM,SidhuAB,Guerrero-BravoJE,Crespo-LladoKN,SerranoAE,LinJW,etal(2011)Aminoindoles,anovelscaffoldwithpotentactivityagainstPlasmodiumfalciparum.AntimicrobAgentsChemother.(15)BookerML,BastosCM,KramerML,BarkerRHJr,SkerljR,SidhuAB,DengX,CelatkaC,CorteseJF,GuerreroBravoJE,CrespoLladoKN,SerranoAE,Angulo-BarturenI,Jiménez-DíazMB,VieraS,GarutiH,WittlinS,PapastogiannidisP,LinJW,etal(2010)NovelinhibitorsofPlasmodiumfalciparumdihydroorotatedehydrogenasewithanti-malarialactivityinthemousemodel.JBiolChem.

1.职称：研究员2.学历：博士3.研究方向：运用系统免疫学方法研究机体对包括疟疾在内传染病的反应；利用系统生物学手段及基因修饰技术研究筛选新药、疫苗靶点。4.邮箱：lin.jingwen@scu.edu.cn5.个人经历2016年12月－至今，四川大学华西第二医院研究员2013年3月－2016年10月，UKMedicalResearchCouncilCareerDevelopmentFellow，TheFrancisCrickInstitute(原NationalInstituteforMedicalResearch)，英国2008年10月－2013年2月，博士，LeidenUniversityMedicalCenter，荷兰6.代表论文：(1)LinJW*,SodenkampJ,CunninghamD,etal,LanghorneJ*(2017).Signaturesofmalaria-associatedpathologyrevealedbyhigh-resolutionwhole-bloodtranscriptomicsinarodentmodelofmalaria.SciRep.(co-correspondingauthors).(2)BrugatT,ReidAJ,LinJW,etal(2016).Antibody-independentclonalselectionregulatestheestablishmentofchronicPlasmodiuminfection.NatureMicrobiology.(3)CapucciniB,LinJ,Talavera-LópezC,etal(2016).Transcriptomicprofilingofmicrogliarevealssignaturesofcellactivationandimmuneresponse,duringexperimentalcerebralmalaria.SciRep.(4)LinJW,SpaccapeloR,SchwarzerE,etal(2015).ReplicationofPlasmodiuminreticulocytescanoccurwithouthemozoinformation,resultinginchloroquineresistance.JExpMed.(5)SalmanAM,MogollonCM,LinJW,etal(2015).Generationoftransgenicrodentmalariaparasitesexpressinghuman-malariaparasiteproteins.MethodsMolBiol.(6)LinJW,ShawTN,BouchierP,etal(2014)ThesubcellularlocationofovalbumininPlasmodiumbergheibloodstagesinfluencesthemagnitudeofT-cellresponses.InfectImmun.(7)EzougouCN,Ben-RachedF,MossDK,LinJW,etal(2014)PlasmodiumfalciparumRab5BisN-terminallymyristoylatedandtargetedtotheparasite’splasmaandfoodvacuolemembranes.PLoSOne.(8)LinJW,MeirelesP,PrudêncioM,etal(2013)Loss-of-functionanalysesdefinesvitalandredundantfunctionsoftheplasmodiumrhomboidproteasefamily.MolecularMicrobiology.(9)AnnouraT,vanSchaijkBCL,PloemenIHJ,SajidM,LinJW,etal(2013)NewmembersofthePlasmodium6-Cysfamilyhavedistinctandcriticalrolesinliverstagedevelopment.FASEBJ(10)DeroostK,TybergheinA,LaysN,NoppenS,SchwarzerE,VanstreelsE,KomutaM,PratoM,LinJW,etal(2013)Hemozoininduceslunginflammationandcorrelateswithmalaria-associatedacuterespiratorydistresssyndrome.AmJRespirCellMolBiol(11)LinJW,SajidM,RamesarJ,KhanSM,JanseCJ,Franke-FayardB.(2011).ScreeninginhibitorsofP.bergheibloodstagesusingbioluminescentreporterparasites.MethodsMolBiol.(12)LinJW,AnnouraT,SajidM,Chevalley-MaurelS,RamesarJ,KlopO,Franke-FayardB,JanseCJ,KhanSM(2011)Anovel‘geneinsertion/markerout’(GIMO)methodfortransgeneex-x-pressionandgenecomplementationinrodentmalariaparasites.PLoSOne.(13)BaluB,MaherSP,PanceA,ChauhanC,NaumovAV,AndrewsRM,EllisPD,KhanSM,LinJW,etal(2011)CCR4-associatedfactor1coordinatestheex-x-pressionofPlasmodiumfalciparumegressandinvasionproteins.EukaryotCell.(14)BarkerRHJr,UrgaonkarS,MazitschekR,CelatkaC,SkerljR,CorteseJF,TyndallE,LiuH,CromwellM,SidhuAB,Guerrero-BravoJE,Crespo-LladoKN,SerranoAE,LinJW,etal(2011)Aminoindoles,anovelscaffoldwithpotentactivityagainstPlasmodiumfalciparum.AntimicrobAgentsChemother.(15)BookerML,BastosCM,KramerML,BarkerRHJr,SkerljR,SidhuAB,DengX,CelatkaC,CorteseJF,GuerreroBravoJE,CrespoLladoKN,SerranoAE,Angulo-BarturenI,Jiménez-DíazMB,VieraS,GarutiH,WittlinS,PapastogiannidisP,LinJW,etal(2010)NovelinhibitorsofPlasmodiumfalciparumdihydroorotatedehydrogenasewithanti-malarialactivityinthemousemodel.JBiolChem.

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