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所在医院：四川大学华西第二医院三级甲等

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展开 1.职称：研究员、优秀青年3.研究方向：运用生物信息学的方法结合分子生物学技术研究疾病的发生机制；致力于研究可变剪接在干细胞分化、癌症等疾病发生等方面的作用机理。4.邮件：luchen@scu.edu.cn5.个人经历：2011年6月－2016年8月博士后经历(剑桥大学，桑格研究所，英国)2008年10月－2011年6月博士学位(巴斯大学,英国)6.代表性论文：（1）ChenL,BingG,CasaleFPetal.2016.Geneticdriversofepigeneticandtranscriptionalvariationinhumanimmunecells.Cell(inpress)（2）AstleWJ,EldingH,JiangTetal.(includingChenL).2016.Thousandsofgeneticvariantsmodulatebloodcellvariationandfunctioninhumans.Cell(inpress)（3）IotchkovaV,HuangJ,MorrisJAetal.(includingChenL).2016.Discoveryandrefinementofgeneticlociassociatedwithcardiome-x-tabolicriskusingdenseimputationmaps.Naturegeneticsdoi:10.1038/ng.3668.（4）PolfusLM,KhajuriaRK,SchickUMetal.(includingChenL).Whole-ExomeSequencingIdentifiesLociAssociatedwithBloodCellTraitsandRevealsaRoleforAlternativeGFI1BSpliceVariantsinHumanHematopoiesis.TheAmericanJournalofHumanGenetics.99(2),481-488（5）TheUK10KConsortium(includingChenL).2015.TheUK10Kproject:rarevariantsinhealthanddisease.Nature526(7571):82-90（6）VasquezL,MannLA,ChenL,SoranzoN.2015.FromGWAStofunction:lessonsfrombloodcells.ISBTScienceSeries(0),1–9（7）Tovar-CoronaJM,Castillo-MoralesA,ChenLetal.2015.Alternativespliceinalternativelice.Molecularbiologyandevolution,32(10),2749-2759（8）ChenL,KostadimaM,MartensJHetal.2014.Transcriptionaldiversityduringlineagecommitmentofhumanbloodprogenitors.Science345(6204):1251033.(HighlightedinNatureReviewsGenetics).（9）ChenL,BushSJ,Tovar-CoronaJMetal.2014.CorrectingforDifferentialTranscriptCoverageRevealsaStrongRelationshipbetweenAlternativeSplicingandOrganismComplexity.Molecularbiologyandevolution31(6):1402-1413.（10）ShinSY,FaumanEB,PetersenAK(includingChenL)etal.2014.Anatlasofgeneticinfluencesonhumanbloodme-x-tabolites.Naturegenetics46(6):543-550.（11）TimpsonNJ,WalterK,MinJL(includingChenL)etal.2014.ArarevariantinAPOC3isassociatedwithplasmatriglycerideandVLDLlevelsinEuropeans.Nat.commun.5:4871.（12）BushSJ,Castillo-MoralesA,Tovar-CoronaJM,ChenLetal.2014.Presence-AbsenceVariationinA-thalianaIsPrimarilyAssociatedwithGenomicSignaturesConsistentwithRelaxedSelectiveConstraints.Molecularbiologyandevolution31(1):59-69.（13）WuXM,TronholmA,CaceresEF（includingChenL)etal.2013.EvidenceforDeepPhylogeneticConservationofExonicSplice-RelatedConstraints:Splice-RelatedSkewsatExonicEndsintheBrownAlgaEctocarpusAreCommonandResembleThoseSeeninHumans.Genomebiologyandevolution5(9):1731-1745.（14）ChenL,Tovar-CoronaJM,UrrutiaAO.2012.Alternativesplicing:apotentialsourceoffunctionalinnovationintheeukaryoticgenome.IntJEvolBiol2012:596274.(Review)（15）ChenL,Tovar-CoronaJM,UrrutiaAO.2011.Increasedlevelsofnoisysplicingincancers,butnotforoncogene-derivedtranscripts.Humanmoleculargenetics20(22):4422-4429（16）ChenL,ZhangQJ,WangW,WangYQ.2010.Spatiotemporalex-x-pressionofPaxgenesinamphioxus:insightsintoPax-relatedorganogenesisandevolution.SciChinaLifesci53(8):1031-1040.

1.职称：研究员、优秀青年3.研究方向：运用生物信息学的方法结合分子生物学技术研究疾病的发生机制；致力于研究可变剪接在干细胞分化、癌症等疾病发生等方面的作用机理。4.邮件：luchen@scu.edu.cn5.个人经历：2011年6月－2016年8月博士后经历(剑桥大学，桑格研究所，英国)2008年10月－2011年6月博士学位(巴斯大学,英国)6.代表性论文：（1）ChenL,BingG,CasaleFPetal.2016.Geneticdriversofepigeneticandtranscriptionalvariationinhumanimmunecells.Cell(inpress)（2）AstleWJ,EldingH,JiangTetal.(includingChenL).2016.Thousandsofgeneticvariantsmodulatebloodcellvariationandfunctioninhumans.Cell(inpress)（3）IotchkovaV,HuangJ,MorrisJAetal.(includingChenL).2016.Discoveryandrefinementofgeneticlociassociatedwithcardiome-x-tabolicriskusingdenseimputationmaps.Naturegeneticsdoi:10.1038/ng.3668.（4）PolfusLM,KhajuriaRK,SchickUMetal.(includingChenL).Whole-ExomeSequencingIdentifiesLociAssociatedwithBloodCellTraitsandRevealsaRoleforAlternativeGFI1BSpliceVariantsinHumanHematopoiesis.TheAmericanJournalofHumanGenetics.99(2),481-488（5）TheUK10KConsortium(includingChenL).2015.TheUK10Kproject:rarevariantsinhealthanddisease.Nature526(7571):82-90（6）VasquezL,MannLA,ChenL,SoranzoN.2015.FromGWAStofunction:lessonsfrombloodcells.ISBTScienceSeries(0),1–9（7）Tovar-CoronaJM,Castillo-MoralesA,ChenLetal.2015.Alternativespliceinalternativelice.Molecularbiologyandevolution,32(10),2749-2759（8）ChenL,KostadimaM,MartensJHetal.2014.Transcriptionaldiversityduringlineagecommitmentofhumanbloodprogenitors.Science345(6204):1251033.(HighlightedinNatureReviewsGenetics).（9）ChenL,BushSJ,Tovar-CoronaJMetal.2014.CorrectingforDifferentialTranscriptCoverageRevealsaStrongRelationshipbetweenAlternativeSplicingandOrganismComplexity.Molecularbiologyandevolution31(6):1402-1413.（10）ShinSY,FaumanEB,PetersenAK(includingChenL)etal.2014.Anatlasofgeneticinfluencesonhumanbloodme-x-tabolites.Naturegenetics46(6):543-550.（11）TimpsonNJ,WalterK,MinJL(includingChenL)etal.2014.ArarevariantinAPOC3isassociatedwithplasmatriglycerideandVLDLlevelsinEuropeans.Nat.commun.5:4871.（12）BushSJ,Castillo-MoralesA,Tovar-CoronaJM,ChenLetal.2014.Presence-AbsenceVariationinA-thalianaIsPrimarilyAssociatedwithGenomicSignaturesConsistentwithRelaxedSelectiveConstraints.Molecularbiologyandevolution31(1):59-69.（13）WuXM,TronholmA,CaceresEF（includingChenL)etal.2013.EvidenceforDeepPhylogeneticConservationofExonicSplice-RelatedConstraints:Splice-RelatedSkewsatExonicEndsintheBrownAlgaEctocarpusAreCommonandResembleThoseSeeninHumans.Genomebiologyandevolution5(9):1731-1745.（14）ChenL,Tovar-CoronaJM,UrrutiaAO.2012.Alternativesplicing:apotentialsourceoffunctionalinnovationintheeukaryoticgenome.IntJEvolBiol2012:596274.(Review)（15）ChenL,Tovar-CoronaJM,UrrutiaAO.2011.Increasedlevelsofnoisysplicingincancers,butnotforoncogene-derivedtranscripts.Humanmoleculargenetics20(22):4422-4429（16）ChenL,ZhangQJ,WangW,WangYQ.2010.Spatiotemporalex-x-pressionofPaxgenesinamphioxus:insightsintoPax-relatedorganogenesisandevolution.SciChinaLifesci53(8):1031-1040.

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