陈小章

展开 1.职称教授2.学历博士3.联系电话86-28-85502290;4.电子邮箱hsiaocchan@cuhk.edu.hk5.研究方向上皮细胞生物学，生殖生理学6.简历:四川大学－香港中文大学生殖医学联合实验室主任,香港中文大学医学院李嘉诚生理学讲座教授，博士生导师。国家自然科学奖（二等，2008），全国妇幼健康科学技术奖（科学成果奖，一等，2015），多次获上海、浙江等省市科学技术奖。于1999年建立了中国较早的一个上皮细胞生物学研究中心，长期以来致力于上皮细胞生物学和生殖生物学的研究，并推动相关领域在中国的发展，取得了一系列国际领跑的成果，先后在Science，NatureCellBiology，NatureMedicine,Lancet，PNAS等高影响因子杂志发表论文近200余篇,累积被引用次数近3000次。她同时担任《Physiology》，《JournalofPhysiologicalSciences》，《CellBiologyInternational》，《中国科学》，《生殖与发育生物学》，《生殖与避孕》等多个国内、国际科学期刊的编委；曾担任世界卫生组织WHO，美国国家科学基金会，英国WelcomeTrust以及中国，德国，意大利。以色列和奥地利等多个国家基金组织的课题评审员。先后领导或参与包括科技部973，国家自然科学基金及香港、国际等20多个重大科研项目。在上皮细胞生物学和生殖生物学相关领域具有深厚的学术背景，并享有很高的学术声誉。2009年创建并主持设于四川大学华西第二医院的四川大学—香港中文大学生殖医学联合实验室，并以此作为推动内地与香港合作的一个重要平台。DirectorofSichuanUniversity-ChineseUniversityofHongKongJointLaboratoryforReproductiveMedicine，alsoLiKaShingProfessorofPhysiologyoftheChineseUniversityofHongKong..ShehasestablishedthefirstEpithelialCellBiologyResearchCenterinChinain1999,andhassincethencommittedtotheepithelialcellbiologyandreproductivebiologyresearchandpromotedthedevelopmentofrelatedfieldsinChina,herworkhaspublishedinaseriesofleadinginternationaljournalsincludingScience,NatureCellBiology,Lancet,PNASpublishednearly200articles,andhasbeencitednear3000times.Shealsoservededitorialboardsinthe"Physiology",“JournalofPhysiologicalSciences”,CellBiologyInternational","ChineseScience","ReproductiveandDevelopmentalBiology","Reproductionandcontraception”andotherinternationalscientificjournals;andservedasareviewerforgrantapplicationstotheWorldHealthOrganization(WHO),theU.S.nationalScienceFoundation,theBritishWelcomeTrustetc.Shehasledorparticipatedin“973”,theNationalNaturalScienceFoundationandtheHongKong“RGC”over20majorresearchprojects,thusenjoyedahighacademicreputationintheepithelialcellbiologyandrelatedfields.Createdin2009,theSichuanUniversity-ChineseUniversityofHongKongJointLaboratoryofReproductiveMedicinelocatedinWestChinaSecondUniversityHospitalofSichuanUniversity,andservedasanimportantplatformtopromotecooperationbetweentheMainlandChinaandHongKong.7.代表性论文：（1）J.H.Guo,H.Chen,Y.C.Ruan,X.L.Zhang,X.H.Zhang,K.L.Fok,L.L.Tsang,M.K.Yu,W.Q.Huang,X.Sun,Y.W.Chung,X.Jiang,Y.Sohma,H.C.Chan,Glucose-inducedelectricalactivitiesandinsulinsecretioninpancreaticisletbeta-cellsaremodulatedbyCFTR,NatCommun5(2014)4420.（2）DiaoR,FokKL,ChenH,YuMK,DuanY,ChungCM,LiZ,WuH,LiZ,ZhangH,JiZ,ZhenW,NgCF,GuiY,CaiZ,ChanHC.Deficienthumanβ-defensin1underliesmaleinfertilityassociatedwithpoorspermmotilityandgenitaltractinfection.SciTranslMed.2014Aug13;6(249):249ra108.（3）G.Guo,X.Sun,C.Chen,S.Wu,P.Huang,Z.Li,M.Dean,Y.Huang,W.Jia,Q.Zhou,A.Tang,Z.Yang,X.Li,P.Song,X.Zhao,R.Ye,S.Zhang,Z.Lin,M.Qi,S.Wan,L.Xie,F.Fan,M.L.Nickerson,X.Zou,X.Hu,L.Xing,Z.Lv,H.Mei,S.Gao,C.Liang,Z.Gao,J.Lu,Y.Yu,C.Liu,L.Li,X.Fang,Z.Jiang,J.Yang,C.Li,X.Zhao,J.Chen,F.Zhang,Y.Lai,Z.Lin,F.Zhou,H.Chen,H.C.Chan,S.Tsang,D.Theodorescu,Y.Li,X.Zhang,J.Wang,H.Yang,Y.Gui,J.Wang,Z.Cai,Whole-genomeandwhole-exomesequencingofbladdercanceridentifiesfrequentalterationsingenesinvolvedinsisterchromatidcohesionandsegregation,NatGenet45(12)(2013)1459-63.（4）Y.C.Ruan,J.H.Guo,X.Liu,R.Zhang,L.L.Tsang,J.D.Dong,H.Chen,M.K.Yu,X.Jiang,X.H.Zhang,K.L.Fok,Y.W.Chung,H.Huang,W.L.Zhou,H.C.Chan,ActivationoftheepithelialNa+channeltriggersprostaglandinE(2)releaseandproductionrequiredforembryoimplantation,NatMed18(7)(2012)1112-7.（5）.Y.C.Lu,H.Chen,K.L.Fok,L.L.Tsang,M.K.Yu,X.H.Zhang,J.Chen,X.Jiang,Y.W.Chung,A.C.Ma,A.Y.Leung,H.F.Huang,H.C.Chan,CFTRmediatesbicarbonate-dependentactivationofmiR-125binpreimplantationembryodevelopment,Cellresearch22(10)(2012)1453-66.（6）.C.Xie,X.H.Jiang,J.T.Zhang,T.T.Sun,J.D.Dong,A.J.Sanders,R.Y.Diao,Y.Wang,K.L.Fok,L.L.Tsang,M.K.Yu,X.H.Zhang,Y.W.Chung,L.Ye,M.Y.Zhao,J.H.Guo,Z.J.Xiao,H.Y.Lan,C.F.Ng,K.M.Lau,Z.M.Cai,W.G.Jiang,H.C.Chan,CFTRsuppressestumorprogressionthroughmiR-193btargetingurokinaseplasminogenactivator(uPA)inprostatecancer,Oncogene32(18)(2013)2282-91,2291e1-7（7）.LiuY,JiangX,ZhangX,ChenR,SunT,FokKL,DongJ,TsangLL,YiS,RuanY,GuoJ,YuMK,TianY,ChungYW,YangM,XuW,ChungCM,LiT,ChanHC.(2011)Dedifferentiation-reprogrammedmesenchymalstemcellswithimprovedtherapeuticpotential.StemCells.29(12):2077-89.（8）.ZhangWK,WangD,DuanY,LoyMM,ChanHC,HuangP.(2010)MechanosensitivegatingofCFTR.NatureCellBiology.12(7):507-512.（9）.ChanHC,RuanYC,HeQ,ChenMH,ChenH,XuWM,ChenWY,XieC,ZhangXH,ZhouZ(2009),Thecysticfibrosistransmembraneconductanceregulatorinreproductivehealthanddisease.JPhysiol.587(Pt10):2187-95.（10）.YinLL,ChungCM,ChenJ,FokKL,NgCP,JiaRR,RenX,ZhouJ,ZhangT,ZhaoXH,LinM,ZhuH,ZhangXH,TsangLL,BiY,ZhouZ,MoF,WongN,ChungYW,ShaJ,ChanHC(2008),Asuppressorofmultipleextracellularmatrix-degradingproteasesandcancerme-x-tastasis.JCellMolMed.13(9B):4034-41.（11）.XuWM,ShiQX,ChenWY,ZhouCX,NiY,RowlandsDK,YiLG,ZhuH,MaZG,WangXF,ChenZH,ZhouSC,DongHS,ZhangXH,ChungYW,YuanYY,YangWX,ChanHC.(2007)Cysticfibrosistransmembraneconductanceregulatorisvitaltospermfertilizingcapacityandmalefertility.ProcNatlAcadSciUSA104:9816-9821.（12）.YinX,OuyangS,XuW,ZhangX,FokKL,WongHY,ZhangJ,QiuX,MiaoS,ChanHC,WangL(2007),YWK-IIproteinasanovelGo-coupledreceptorforMullerianinhibitingsubstanceincellsurvival.JournalofCellScience.120:1521-8.（13）.ZhouCX,ZhangYL,XiaoLQ,ZhengM,LeungKM,ChanMY,LoPS,WongHY,HoLS,ChungYWandChanHC.(2004)Anepididymis-specific-defensininvolvedininitiationofspermmaturation.NatureCellBiology6:458-464.（14）.WangXF,ZhouCX,ShiQX,YuanYY,YuMK,HoLS,AjonumaLC,LoPS,LamSYTsangLL,ChanLN,ZhaoWC,ChungYW,andChanHC.(2003)InvolvementofCFTRinuterinebicarbonatesecretionandthefertilizingcapacityofsperm.NatureCellBiology5:902-906.（15）.ZhuH,ZhuJX,LoPS,LeungKM,RowlandsDK,TsangLL,YuMK,LamSYJiangJL,ChanLN,ChungYW,ZhouZM,ShaJH,ChanHC.(2003)RescueofdefectivepancreaticductsecretionincysticfibrosiscellsbysuppressionofanovelphospholipaseCisoform.Lancet362:2059-2065.（16）.LiP,ChanHC,HeB,SoSC,ChungYW,ShangQ,ZhangYD&ZhangYL.(2001)Anantimicrobialpeptidegenefoundinthemalereproductivesystemofrats.Science291:1783-1785.（17）.ChanHC,FongSK,SoSC,ChungYWandWongPY(1997),Stimulationofanionsecretionbybeta-adrenoceptorsinthemouseendometrialepithelium.JPhysiol.501(Pt3):517-25.（18）.ChanHCandNelsonDJ(1992),Chloride-dependentcationconductanceactivatedduringcellularshrinkage.Science.257(5070):669-71.